150 research primates got diarrhea, flooding lab with priceless vaccine data
摘要
一项持续两年多的疫情中，某研究中心逾150只非人灵长类动物感染腹泻，却意外为科学家提供了宝贵数据。研究发表于《科学转化医学》，团队从感染免疫数据中筛选出免疫细胞对抗志贺氏菌的新方法，识别出免疫系统最有效攻击的细菌特定片段，并将靶分子与杀菌免疫反应类型关联，甚至精确定位了最强抗体结合的微小位点。作者称，该研究揭示了自然感染中抗志贺氏菌抗体反应的意外特征，为合理
Having more than 150 non-human primates at a research center fall ill with diarrhea in a stomach-churning outbreak that flowed for over two years doesn't sound much like good fortune. But for some scientists, it kind of was, providing a heaping pile of valuable data on how they might finally defeat a foul foe.
In a study published in the latest issue of Science Translational Medicine, scientist sifted through the dump of immunological data from the infections, logging new ways to train immune cells to defeat the bacteria behind the outbreak, a type of Shigella. Researchers were able to pluck out specific bits of the bacteria that the immune system could most effectively attack, linking specific target molecules to specific types of germ-busting immune responses. The researchers even precisely homed in on some of the tiny notches within those craggy target molecules where the most potent antibodies attached.
In all, the study "revealed unexpected features of the anti-Shigella antibody response in naturally infected [non-human primates] and represents a step toward the rational design of Shigella vaccine candidates," the authors write.
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